Calculate C(t) for a 3-compartment linear model
Usage
calc_sd_3cmt(t, dose, dur = NULL, tinf = NULL, ...)
calc_sd_3cmt_linear_bolus(t, dose, ...)
calc_sd_3cmt_linear_oral_1_lag(t, dose, ...)
calc_sd_3cmt_linear_infusion(t, dose, tinf, ...)
calc_sd_3cmt_linear_oral_0(t, dose, dur, ...)
calc_sd_3cmt_linear_oral_0_lag(t, dose, dur, ...)
calc_sd_3cmt_linear_oral_1(t, dose, ...)
Arguments
- t
Time after dose (h)
- dose
Dose
- dur
Duration of zero-order absorption (h)
- tinf
Duration of infusion (h)
- ...
Passed to
calc_derived_3cpt()
Value
Concentration of drug at requested time (t
) after a single dose, given provided set of parameters and variables.
Functions
calc_sd_3cmt_linear_bolus()
: Calculate C(t) for a 3-compartment linear model after a single IV bolus dosecalc_sd_3cmt_linear_oral_1_lag()
: Calculate C(t) for a 3-compartment linear model after a single oral dosecalc_sd_3cmt_linear_infusion()
: Calculate C(t) for a 3-compartment linear model after a single IV infusioncalc_sd_3cmt_linear_oral_0()
: Calculate C(t) for a 3-compartment linear model after a single dose, with zero-order absorptioncalc_sd_3cmt_linear_oral_0_lag()
: Calculate C(t) for a 3-compartment linear model after a single dose, with zero-order absorption and a lag timecalc_sd_3cmt_linear_oral_1()
: Calculate C(t) for a 3-compartment linear model after a single oral dose
References
Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. https://www.facm.ucl.ac.be/cooperation/Vietnam/WBI-Vietnam-October-2011/Modelling/Monolix32_PKPD_library.pdf
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.
Examples
Ct <- calc_sd_3cmt_linear_bolus(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
V3 = 200, Q2 = 0.5, Q3 = 0.05, dose = 100)
Ct <- calc_sd_3cmt_linear_oral_1_lag(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
V3 = 200, Q2 = 0.5, Q3 = 0.05, ka = 1, dose = 100, tlag = 1.5)
Ct <- calc_sd_3cmt_linear_infusion(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
V3 = 200, Q2 = 0.5, Q3 = 0.05, dose = 100, tinf=1)
Ct <- calc_sd_3cmt_linear_oral_0(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
V3 = 200, Q2 = 0.5, Q3 = 0.05, dur = 1, dose = 100)
Ct <- calc_sd_3cmt_linear_oral_0_lag(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
V3 = 200, Q2 = 0.5, Q3 = 0.05, dur = 1, dose = 100, tlag=1.5)
Ct <- calc_sd_3cmt_linear_oral_1(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
V3 = 200, Q2 = 0.5, Q3 = 0.05, ka = 1, dose = 100)