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Calculate C(t) for a 2-compartment linear model

Source: R/calc_2cmt.R
calc_sd_2cmt.Rd

Calculate C(t) for a 2-compartment linear model

Usage

calc_sd_2cmt(t, dose, dur = NULL, tinf = NULL, ...)

calc_sd_2cmt_linear_bolus(t, dose, ...)

calc_sd_2cmt_linear_oral_1_lag(t, dose, ...)

calc_sd_2cmt_linear_infusion(t, dose, tinf, ...)

calc_sd_2cmt_linear_oral_0_lag(t, dose, dur, ...)

calc_sd_2cmt_linear_oral_1(t, dose, ...)

calc_sd_2cmt_linear_oral_0(t, dose, dur, ...)

Arguments

t

Time after dose (h)

dose

Dose

dur

Duration of zero-order absorption (h)

tinf

Duration of infusion (h)

...

Passed to calc_derived_2cpt()

Value

Concentration of drug at requested time (t) after a single dose, given provided set of parameters and variables.

Functions

  • calc_sd_2cmt_linear_bolus(): Calculate C(t) for a 2-compartment linear model after a single IV bolus dose

  • calc_sd_2cmt_linear_oral_1_lag(): Calculate C(t) for a 2-compartment linear model after a single first-order oral dose with a lag time

  • calc_sd_2cmt_linear_infusion(): Calculate C(t) for a 2-compartment linear model after a single infusion

  • calc_sd_2cmt_linear_oral_0_lag(): Calculate C(t) for a 2-compartment linear model after a single zero-order oral dose, with lag time

  • calc_sd_2cmt_linear_oral_1(): Calculate C(t) for a 2-compartment linear model after a single first-order oral dose

  • calc_sd_2cmt_linear_oral_0(): Calculate C(t) for a 2-compartment linear model after a single zero-order oral dose

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. https://www.facm.ucl.ac.be/cooperation/Vietnam/WBI-Vietnam-October-2011/Modelling/Monolix32_PKPD_library.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Author

Justin Wilkins, justin.wilkins@occams.com

Bill Denney, wdenney@humanpredictions.com

Examples

Ct <- calc_sd_2cmt_linear_bolus(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5, dose = 10)
Ct <- calc_sd_2cmt_linear_oral_1_lag(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, ka = 1, tlag = 2)
Ctrough <- calc_sd_2cmt_linear_infusion(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 10, tinf = 1)
Ctrough <- calc_sd_2cmt_linear_oral_0_lag(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1, tlag=2)
Ct <- calc_sd_2cmt_linear_oral_1(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, ka = 1)
Ct <- calc_sd_2cmt_linear_oral_0(t = 11.75, CL = 7.5, V1 = 20, V2 = 30, Q = 0.5,
    dose = 1000, dur = 1)